Aloperine suppresses the proliferation, migration and invasion of human liver cancer cells via induction of G₂/M cell cycle arrest and inhibition of GROα expression

Aloperine has been shown to exhibit tremendous pharmacological potential. The present study was designed investigate the effects of aloperine against human liver cancer cells and explore underlying mechanism. results showed significant (P < .05) upregulation GROα (GRO1 oncogene) in tissues cell lines. However, expression significantly declined treated with (5 µM) which concomitant inhibition proliferation. Silencing inhibited proliferation via G2/M cycle arrest. Interestingly, also triggered arrest cells. Nonetheless, growth inhibitory on were attenuated by overexpression did not show division. Additionally, suppressed migration, invasion epithelial mesenchymal transition expression. Collectively, findings revealed suppression point toward its therapeutic